Association of TIMP4 gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China.

ABSTRACT:

Background

In clinical treatment, the use of steroid hormones is an important etiological factor of non-traumatic osteonecrosis of the femoral head (ONFH) risk. As an endogenous inhibitor of matrix metalloproteinases (MMPs) in the extracellular matrix, the expression of tissue inhibitors of metalloprotease-4 (TIMP4) plays an essential role in cartilage and bone tissue damage and remodeling, vasculitis formation, intravascular thrombosis, and lipid metabolism.

Methods

This study aimed to detect the association between TIMP4 polymorphism and steroid-induced ONFH. We genotyped seven single-nucleotide polymorphisms (SNPs) in TIMP4 genes and analyzed the association with steroid-induced ONFH from 286 steroid-induced ONFH patients and 309 normal individuals.

Results

We perf

SUBMITTER: Wang J 

PROVIDER: S-EPMC6348097 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature