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[Research Advances of JAK/STAT Signaling Pathway in Lung Cancer].

ABSTRACT: Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. In recent years, with the further research of JAK/STAT signaling pathway, it has been found that the pathway also plays a key role in the development of solid tumors. Here we reviewed the research advances of JAK/STAT signaling pathway in lung cancer, especially the mechanisms of development, metastasis and drug resistance, and the application of inhibitors which targeting JAK/STAT signaling pathway in the treatment of lung cancer.?.

SUBMITTER: Yang X

PROVIDER: S-EPMC6348154 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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[Research Advances of JAK/STAT Signaling Pathway in Lung Cancer].

Yang Xin X Tang Zhe Z Zhang Peng P Zhang Li L

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20190101 1

Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. In recent years, with the further research of JAK/STAT signaling pathway, it ...[more]

PMID: 30674393

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