Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
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ABSTRACT:
SUBMITTER: Imanishi T
PROVIDER: S-EPMC6348487 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function.
Imanishi Takayuki T Unno Midori M Kobayashi Wakana W Yoneda Natsumi N Matsuda Satoshi S Ikeda Kazutaka K Hoshii Takayuki T Hirao Atsushi A Miyake Kensuke K Barber Glen N GN Arita Makoto M Ishii Ken J KJ Akira Shizuo S Saito Takashi T
Life science alliance 20190125 1
Stimulator of interferon genes (STING) plays a key role in detecting cytosolic DNA and induces type I interferon (IFN-I) responses for host defense against pathogens. Although T cells highly express STING, its physiological role remains unknown. Here, we show that costimulation of T cells with the STING ligand cGAMP and TCR leads to IFN-I production and strongly inhibits T-cell growth. TCR-mediated mTORC1 activation and sustained activation of IRF3 are required for cGAMP-induced IFN-I production ...[more]
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