Ontology highlight
ABSTRACT:
SUBMITTER: Liu YY
PROVIDER: S-EPMC6348597 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Experimental biology and medicine (Maywood, N.J.) 20181119 17-18
<h4>Impact statement</h4>Mechanical ventilation (MV) is life-saving for patients with acute respiratory failure but also causes difficult liberation of patients from ventilator due to rapid decrease of diaphragm muscle endurance and strength, which is termed ventilator-induced diaphragmatic damage (VIDD). Numerous studies have revealed that VIDD could increase extubation failure, ICU stay, ICU mortality, and healthcare expenditures. However, the mechanisms of VIDD, potentially involving a multis ...[more]