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Callous-Unemotional Traits Moderate Genetic and Environmental Influences on Rule-Breaking and Aggression: Evidence for Gene × Trait Interaction.

ABSTRACT: Previous behavioral genetic research in children has found that conduct problems in the presence of high CU traits are more heritable than conduct problems in the presence of low CU traits -- a gene × trait interaction. The current study replicates and extends this finding using a sample of adolescent twins from the Texas Twin Project, who were assessed for rule-breaking and aggression. We find evidence that genetic influences on CU traits contribute to genetic liability for both rule-breaking and aggressive behavior. CU traits moderate genetic influences on aggressive behavior, such that the heritability of aggression is higher among youth with high levels of CU traits. However, we do not find evidence that CU traits moderate genetic influences on rule-breaking behavior. The continuum of callous-unemotionality and the aggression versus rule-breaking distinction continues to be meaningful and intersecting methods for characterizing heterogeneity in the etiology of antisocial behavior.

SUBMITTER: Mann FD

PROVIDER: S-EPMC6349236 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Callous-Unemotional Traits Moderate Genetic and Environmental Influences on Rule-Breaking and Aggression: Evidence for Gene × Trait Interaction.

Mann Frank D FD Tackett Jennifer L JL Tucker-Drob Elliot M EM Harden K Paige KP

Clinical psychological science : a journal of the Association for Psychological Science 20170928 1

Previous behavioral genetic research in children has found that conduct problems in the presence of high CU traits are more heritable than conduct problems in the presence of low CU traits -- a gene × trait interaction. The current study replicates and extends this finding using a sample of adolescent twins from the Texas Twin Project, who were assessed for rule-breaking and aggression. We find evidence that genetic influences on CU traits contribute to genetic liability for both rule-breaking a ...[more]

PMID: 30701129

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Project description:Aggression and callous, uncaring, and unemotional (CU) traits are clinically related behavioral constructs caused by genetic and environmental factors. We performed polygenic risk score (PRS) analyses to investigate shared genetic etiology between aggression and these three CU-traits. Furthermore, we studied interactions of PRS with smoking during pregnancy and childhood life events in relation to CU-traits. Summary statistics for the base phenotype were derived from the EAGLE-consortium genome-wide association study of children's aggressive behavior and were used to calculate individual-level genome-wide and gene-set PRS in the NeuroIMAGE target-sample. Target phenotypes were 'callousness', 'uncaring', and 'unemotional' sumscores of the Inventory of Callous-Unemotional traits. A total of 779 subjects and 1,192,414 single-nucleotide polymorphisms were available for PRS-analyses. Gene-sets comprised serotonergic, dopaminergic, glutamatergic, and neuroendocrine signaling pathways. Genome-wide PRS showed evidence of association with uncaring scores (explaining up to 1.59% of variance; self-contained Q = 0.0306, competitive-P = 0.0015). Dopaminergic, glutamatergic, and neuroendocrine PRS showed evidence of association with unemotional scores (explaining up to 1.33, 2.00, and 1.20% of variance respectively; self-contained Q-values 0.037, 0.0115, and 0.0473 respectively, competitive-P-values 0.0029, 0.0002, and 0.0045 respectively). Smoking during pregnancy related to callousness scores while childhood life events related to both callousness and unemotionality. Moreover, dopaminergic PRS appeared to interact with childhood life events in relation to unemotional scores. Our study provides evidence suggesting shared genetic etiology between aggressive behavior and uncaring, and unemotional CU-traits in children. Gene-set PRS confirmed involvement of shared glutamatergic, dopaminergic, and neuroendocrine genetic variation in aggression and CU-traits. Replication of current findings is needed.

Dataset Information

Callous-Unemotional Traits Moderate Genetic and Environmental Influences on Rule-Breaking and Aggression: Evidence for Gene × Trait Interaction.

Publications

Callous-Unemotional Traits Moderate Genetic and Environmental Influences on Rule-Breaking and Aggression: Evidence for Gene × Trait Interaction.

Similar Datasets

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