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Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process.


ABSTRACT: Sepsis is a life-threatening dysfunction of the immune system leading to multiorgan failure that is precipitated by infectious diseases and is a leading cause of death in children under 5 years of age. It is necessary to be able to identify a sick child at risk of developing sepsis at the earliest point of presentation to a healthcare facility so that appropriate care can be provided as soon as possible. Our study objective was to generate a list of consensus-driven predictor variables for the derivation of a prediction model that will be incorporated into a mobile device and operated by low-skilled healthcare workers at triage. By conducting a systematic literature review and examination of global guideline documents, a list of 72 initial candidate predictor variables was generated. A two-round modified Delphi process involving 26 experts from both resource-rich and resource-limited settings, who were also encouraged to suggest new variables, yielded a final list of 45 predictor variables after evaluating each variable based on three domains: predictive potential, measurement reliability, and level of training and resources required. The final list of predictor variables will be used to collect data and contribute to the derivation of a prediction model.

SUBMITTER: Fung JST 

PROVIDER: S-EPMC6349330 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process.

Fung Jollee S T JST   Akech Samuel S   Kissoon Niranjan N   Wiens Matthew O MO   English Mike M   Ansermino J Mark JM  

PloS one 20190128 1


Sepsis is a life-threatening dysfunction of the immune system leading to multiorgan failure that is precipitated by infectious diseases and is a leading cause of death in children under 5 years of age. It is necessary to be able to identify a sick child at risk of developing sepsis at the earliest point of presentation to a healthcare facility so that appropriate care can be provided as soon as possible. Our study objective was to generate a list of consensus-driven predictor variables for the d  ...[more]

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