Ontology highlight
ABSTRACT:
SUBMITTER: Zheng J
PROVIDER: S-EPMC6349348 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zheng Jianjian J Mao Yuqing Y Dong Peihong P Huang Zhiming Z Yu Fujun F
Journal of cellular and molecular medicine 20181208 2
HOXA transcript at the distal tip (HOTTIP) has been shown to be up-regulated in a variety of cancers and is identified as an oncogenic long noncoding RNA. However, the biological role of HOTTIP in liver fibrosis is unclear. Here, we reported that HOTTIP was specifically overexpressed in activated hepatic stellate cells (HSCs). HOTTIP knockdown suppressed the activation and proliferation of HSCs. Luciferase reporter assay showed that HOTTIP and serum response factor (SRF) were targets of miR-150. ...[more]