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Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage.

ABSTRACT: BACKGROUND:This study aims to establish age- and gender-specific cystatin C (CysC) reference values for healthy infants, children, and adolescents and to relate them to pubertal stage, height, weight, and body mass index (BMI). METHODS:Serum CysC and creatinine levels of 6217 fasting, morning venous blood samples from 2803 healthy participants of the LIFE Child study (age 3 months to 18 years) were analyzed by an immunoassay. Recruitment started in 2011; 1636 participants provided at least one follow-up measurement. Percentiles for CysC were calculated. Age- and gender-related effects of height, weight, BMI, and puberty status were assessed through linear regression models. RESULTS:Over the first 2 years of life, median CysC levels decrease depending on height (ß?=?-?0.010 mg/l/cm, p?

SUBMITTER: Ziegelasch N

PROVIDER: S-EPMC6349798 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Cystatin C serum levels in healthy children are related to age, gender, and pubertal stage.

Ziegelasch Niels N Vogel Mandy M Müller Eva E Tremel Nadin N Jurkutat Anne A Löffler Markus M Terliesner Nicolas N Thiery Joachim J Willenberg Anja A Kiess Wieland W Dittrich Katalin K

Pediatric nephrology (Berlin, Germany) 20181120 3

<h4>Background</h4>This study aims to establish age- and gender-specific cystatin C (CysC) reference values for healthy infants, children, and adolescents and to relate them to pubertal stage, height, weight, and body mass index (BMI).<h4>Methods</h4>Serum CysC and creatinine levels of 6217 fasting, morning venous blood samples from 2803 healthy participants of the LIFE Child study (age 3 months to 18 years) were analyzed by an immunoassay. Recruitment started in 2011; 1636 participants provided ...[more]

PMID: 30460495

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