Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.
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ABSTRACT:
SUBMITTER: Bustos BI
PROVIDER: S-EPMC6349870 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.
Bustos Bernabé I BI Pérez-Palma Eduardo E Buch Stephan S Azócar Lorena L Riveras Eleodoro E Ugarte Giorgia D GD Toliat Mohammad M Nürnberg Peter P Lieb Wolfgang W Franke Andre A Hinz Sebastian S Burmeister Greta G von Schönfels Witigo W Schafmayer Clemens C Völzke Henry H Völker Uwe U Homuth Georg G Lerch Markus M MM Santos José Luis JL Puschel Klaus K Bambs Claudia C Roa Juan Carlos JC Gutiérrez Rodrigo A RA Hampe Jochen J De Ferrari Giancarlo V GV Miquel Juan Francisco JF
Scientific reports 20190128 1
Latin Americans and Chilean Amerindians have the highest prevalence of gallstone disease (GSD) and gallbladder cancer (GBC) in the world. A handful of loci have been associated with GSD in populations of predominantly European ancestry, however, they only explain a small portion of the genetic component of the disease. Here, we performed a genome-wide association study (GWAS) for GSD in 1,095 admixed Chilean Latinos with Mapuche Native American ancestry. Disease status was assessed by cholecyste ...[more]
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