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Anaphylactoid hypersensitivity reaction from intra-arterial cetuximab: Clinical considerations and management.

ABSTRACT: Intra-arterial infusion of drugs shows promising results in terms of safety and efficacy. Intra-arterial cetuximab, a monoclonal antibody treatment, is currently being tested for its use in head and neck cancers. We present the case of a 45-year-old Asian male who developed an anaphylactoid hypersensitivity reaction, manifesting itself in the form of bronchospasm, tachycardia, and hypotension, during intra-arterial infusion of cetuximab. The symptoms were quickly diagnosed, and the patient was treated accordingly. Despite the safety profile of cetuximab and the decreased risk of systemic effects with intra-arterial infusion versus intravenous infusion, severe hypersensitivity reactions are still a risk in intra-arterial cetuximab infusions. Consequently, proper planning and care must be taken to prophylactically prevent and in the case of a reaction, treat the reaction accordingly. The case presented herein is, to the best of our knowledge, the first recorded moderate-to-severe infusion reaction in a patient receiving intra-arterial cetuximab treatment for head and neck cancer.

SUBMITTER: Bardash Y

PROVIDER: S-EPMC6350015 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Anaphylactoid hypersensitivity reaction from intra-arterial cetuximab: Clinical considerations and management.

Bardash Yonatan Y Tham Tristan T Olson Caitlin C Khaymovich Julian J Costantino Peter P

SAGE open medical case reports 20190112

Intra-arterial infusion of drugs shows promising results in terms of safety and efficacy. Intra-arterial cetuximab, a monoclonal antibody treatment, is currently being tested for its use in head and neck cancers. We present the case of a 45-year-old Asian male who developed an anaphylactoid hypersensitivity reaction, manifesting itself in the form of bronchospasm, tachycardia, and hypotension, during intra-arterial infusion of cetuximab. The symptoms were quickly diagnosed, and the patient was t ...[more]

PMID: 30728973

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Dataset Information

Anaphylactoid hypersensitivity reaction from intra-arterial cetuximab: Clinical considerations and management.

Publications

Anaphylactoid hypersensitivity reaction from intra-arterial cetuximab: Clinical considerations and management.

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