Comparative Analysis of Normalization Methods for Network Propagation.
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ABSTRACT:
SUBMITTER: Biran H
PROVIDER: S-EPMC6350446 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Comparative Analysis of Normalization Methods for Network Propagation.
Biran Hadas H Kupiec Martin M Sharan Roded R
Frontiers in genetics 20190122
Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available. Here we propose a novel normalization method for network propagation that is based on evaluating the propagation results against those obtained on randomized networks that preserve node degrees. In this way, our method overcomes potential biases of previous method ...[more]
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