Ontology highlight
ABSTRACT:
SUBMITTER: Martin A
PROVIDER: S-EPMC6350529 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Martin Aline A Quarles L Darryl LD
Advances in experimental medicine and biology 20120101
Bone is involved in the maintenance of phosphate and vitamin D homeostasis via its production and secretion of FGF23 and serves as a reservoir for the storage and release of calcium and phosphate into the circulation. Alterations in mineralization of extracellular matrix and the remodeling activities of the skeleton are coupled to the kidney conservation of phosphate and production of 1,25(OH)2D via the regulation of FGF23 production by osteocytes through yet-to-be defined locally derived factor ...[more]