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ABSTRACT: Purpose
To systematically evaluate the associations between oxidative stress status and different types of glaucoma.Design
Systematic review and meta-analysis.Methods
We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger's test were performed to assess potential publication bias.Main outcome measures
Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma).Results
Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580?mmol/L (p < 0.0001, 95% CI?=?-0.668 to -0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989?U/mL (p < 0.0001, 95% CI?=?14.579-21.298), 12.441?U/mL (p < 0.0001, 95% CI?=?10.423-14.459), and 1.229?fmol/mL (p=0.042, 95% CI?=?0.043-2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262?mmol/L (p < 0.0001, 95% CI?=?-0.393 to -0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group.Conclusions
This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.
SUBMITTER: Tang B
PROVIDER: S-EPMC6350588 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tang Binghua B Li Shengjie S Cao Wenjun W Cao Wenjun W Sun Xinghuai X
Journal of ophthalmology 20190115
<h4>Purpose</h4>To systematically evaluate the associations between oxidative stress status and different types of glaucoma.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A fu ...[more]