Ontology highlight
ABSTRACT:
SUBMITTER: Cappetta D
PROVIDER: S-EPMC6350609 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cappetta Donato D Ciuffreda Loreta Pia LP Cozzolino Anna A Esposito Grazia G Scavone Cristina C Sapio Luigi L Naviglio Silvio S D'Amario Domenico D Crea Filippo F Rossi Francesco F Berrino Liberato L De Angelis Antonella A Urbanek Konrad K
Oxidative medicine and cellular longevity 20190110
Cardiovascular diseases frequently coexist with chronic kidney disease that constitutes a major determinant of outcome in patients with heart failure. Dysfunction of both organs is related to chronic inflammation, endothelial dysfunction, oxidative stress, and fibrosis. Widespread expression of serine protease DPP4 that degrades varieties of substrates suggests its involvement in numerous physiological processes. In this study, we tested the effects of selective DPP4 inhibition on the progressio ...[more]