Ontology highlight
ABSTRACT:
SUBMITTER: Thierbach S
PROVIDER: S-EPMC6350858 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20190121
Selectively methylated analogues of naturally occurring 2-heptyl-4(1<i>H</i>)-quinolones, which are alkaloids common within the Rutaceae family and moreover are associated with quorum sensing and virulence of the human pathogen <i>Pseudomonas aeruginosa</i>, have been prepared. While the synthesis by direct methylation was successful for 3-unsubstituted 2-heptyl-4(1<i>H</i>)-quinolones, methylated derivatives of the <i>Pseudomonas</i> quinolone signal (PQS) were synthesized from 3-iodinated quin ...[more]