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Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double-blind randomized study.

ABSTRACT: INTRODUCTION:Blood donation has been proposed as a potential therapy to reduce risk of cardiovascular disease, but the effects of phlebotomy on vascular function in human subjects have not been well characterized. AIMS:We conducted a prospective randomized double-blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Eighty-four iron-replete, non-anemic subjects were randomly assigned to one of three study treatment groups: (a) four serial phlebotomy procedures each followed by intravenous infusion of placebo normal saline; (b) four serial phlebotomy procedures each followed by intravenous infusion to replete lost iron; and (c) four serial sham phlebotomy procedures each followed by intravenous infusion of placebo normal saline. Assigned phlebotomy procedures were conducted at 56-day intervals. We measured brachial artery reactivity (BAR, %) in response to transient oxidative stress induced by oral methionine with high-resolution duplex ultrasound imaging before and one week after the fourth study phlebotomy. RESULTS:Before phlebotomy, oral methionine decreased BAR by -2.04% (95% CI -2.58%, -1.50%), P < 0.001) with no significant difference between groups (P = 0.42). After phlebotomy, the BAR response to oral methionine did not significantly change between groups (P = 0.53). Brachial artery nitroglycerin-mediated dilation did not change in response to phlebotomy. CONCLUSIONS:Four serial phlebotomy procedures over six months with or without intravenous iron supplementation did not alter vascular endothelial function in the brachial artery when compared with sham phlebotomy.

SUBMITTER: Jelani QU

PROVIDER: S-EPMC6351195 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double-blind randomized study.

Jelani Qurat-Ul-Ain QU Harchandani Bhisham B Cable Ritchard G RG Guo Yu Y Zhong Hua H Hilbert Timothy T Newman Jonathan D JD Katz Stuart D SD

Cardiovascular therapeutics 20181113 6

<h4>Introduction</h4>Blood donation has been proposed as a potential therapy to reduce risk of cardiovascular disease, but the effects of phlebotomy on vascular function in human subjects have not been well characterized.<h4>Aims</h4>We conducted a prospective randomized double-blind study to determine the effects of serial phlebotomy on vascular endothelial function in the brachial artery. Eighty-four iron-replete, non-anemic subjects were randomly assigned to one of three study treatment group ...[more]

PMID: 30341986

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Dataset Information

Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double-blind randomized study.

Publications

Effects of serial phlebotomy on vascular endothelial function: Results of a prospective double-blind randomized study.

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