Ontology highlight
ABSTRACT:
SUBMITTER: Tomaszewski CE
PROVIDER: S-EPMC6351215 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Tomaszewski Claire E CE Constance Elizabeth E Lemke Melissa M MM Zhou Hong H Padmanabhan Vasantha V Arnold Kelly B KB Shikanov Ariella A
Biomaterials science 20190101 2
Development of primary follicles in vitro benefits from a three-dimensional matrix that is enriched with paracrine factors secreted from feeder cells and mimics the in vivo environment. In this study, we investigated the role of paracrine signaling from adipose-derived stem cells (ADSCs) in supporting primary follicle development in a biomimetic poly(ethylene glycol) (PEG)-based matrix. Follicles co-cultured with ADSCs and follicles cultured in conditioned medium from ADSCs encapsulated in gels ...[more]