Ontology highlight
ABSTRACT:
SUBMITTER: Kim D
PROVIDER: S-EPMC6351226 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature nanotechnology 20180709 9
Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation<sup>1,2</sup> and transmission<sup>3,4</sup> of α-synuclein (α-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic. Here, we show that graphene quantum dots (GQDs) inhibit fibrillization of α-syn and interact directly with mature fibrils, triggering their disaggregation. Moreover, GQDs can rescue neuronal dea ...[more]