Ontology highlight
ABSTRACT:
SUBMITTER: Lahesmaa M
PROVIDER: S-EPMC6351510 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
European journal of nuclear medicine and molecular imaging 20180813 3
<h4>Purpose</h4>Brown adipose tissue (BAT) has emerged as a potential target to combat obesity and diabetes, but novel strategies to activate BAT are needed. Adenosine and A<sub>2A</sub> receptor (A2AR) agonism activate BAT in rodents, and endogenous adenosine is released locally in BAT as a by-product of noradrenaline, but physiological data from humans is lacking. The purpose of this pilot study was to investigate the effects of exogenous adenosine on human BAT perfusion, and to determine the ...[more]