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Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.


ABSTRACT: Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25?min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.

SUBMITTER: Jones SE 

PROVIDER: S-EPMC6351539 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.

Jones Samuel E SE   Lane Jacqueline M JM   Wood Andrew R AR   van Hees Vincent T VT   Tyrrell Jessica J   Beaumont Robin N RN   Jeffries Aaron R AR   Dashti Hassan S HS   Hillsdon Melvyn M   Ruth Katherine S KS   Tuke Marcus A MA   Yaghootkar Hanieh H   Sharp Seth A SA   Jie Yingjie Y   Thompson William D WD   Harrison Jamie W JW   Dawes Amy A   Byrne Enda M EM   Tiemeier Henning H   Allebrandt Karla V KV   Bowden Jack J   Ray David W DW   Freathy Rachel M RM   Murray Anna A   Mazzotti Diego R DR   Gehrman Philip R PR   Lawlor Debbie A DA   Frayling Timothy M TM   Rutter Martin K MK   Hinds David A DA   Saxena Richa R   Weedon Michael N MN  

Nature communications 20190129 1


Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 2  ...[more]

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