Ontology highlight
ABSTRACT:
SUBMITTER: Tschuor C
PROVIDER: S-EPMC6351850 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Tschuor Christoph C Kachaylo Ekaterina E Ungethüm Udo U Song Zhuolun Z Lehmann Kuno K Sánchez-Velázquez Patricia P Linecker Michael M Kambakamba Patryk P Raptis Dimitri A DA Limani Përparim P Eshmuminov Dilmurodjon D Graf Rolf R Columbano Amedeo A Humar Bostjan B Clavien Pierre-Alain PA
FASEB bioAdvances 20181127 1
The ability of the liver to restore its original volume following tissue loss has been associated with the Hippo-YAP1 pathway, a key controller of organ size. Yes-associated protein 1 (YAP1)-a growth effector usually restrained by Hippo signaling-is believed to be of particular importance; however, its role in liver regeneration remains ill-defined. To explore its function, we knocked down YAP1 prior to standard 70%-hepatectomy (sHx) using a hepatocyte-specific nanoformulation. Knockdown was eff ...[more]