Amyloid ? perturbs elevated heme flux induced with neuronal development.
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ABSTRACT:
SUBMITTER: Vidal C
PROVIDER: S-EPMC6352316 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Amyloid β perturbs elevated heme flux induced with neuronal development.
Vidal Chantal C Daescu Kelly K Fitzgerald Keely E KE Starokadomska Anna A Bezprozvanny Ilya I Zhang Li L
Alzheimer's & dementia (New York, N. Y.) 20190122
<h4>Introduction</h4>Heme is a central molecule in mitochondrial respiration and ATP generation in neuronal cells. Thus, we assessed the importance of altered heme metabolism in Alzheimer's disease (AD) pathogenesis.<h4>Methods</h4>To investigate the role of altered heme metabolism in AD, we identified heme-related proteins whose expression is altered in AD patients and mouse models exhibiting amyloid pathology. We detected the levels of proteins involved in heme synthesis, uptake, degradation, ...[more]
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