Ontology highlight
ABSTRACT:
SUBMITTER: Janks L
PROVIDER: S-EPMC6352910 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Janks Laura L Sprague Randy S RS Egan Terrance M TM
Journal of immunology (Baltimore, Md. : 1950) 20181231 3
Immune cells of myeloid origin show robust expression of ATP-gated P2X7 receptors, two-transmembrane ion channels permeable to Na<sup>+</sup>, K<sup>+</sup>, and Ca<sup>2+</sup> Receptor activation promotes inflammasome activation and release of the proinflammatory cytokines IL-1β and IL-18. In this study, we show that ATP generates facilitating cationic currents in monocyte-derived human macrophages and permeabilizes the plasma membrane to polyatomic cationic dyes. We find that antagonists of P ...[more]