The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.
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ABSTRACT:
SUBMITTER: Biskou O
PROVIDER: S-EPMC6353089 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.
Biskou Olga O Casanova Victor V Hooper Kirsty M KM Kemp Sadie S Wright Graham P GP Satsangi Jack J Barlow Peter G PG Stevens Craig C
PloS one 20190130 1
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively unexplored. Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytosol t ...[more]
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