Dataset Information

Levodopa-Responsive Parkinsonism Associated with Giant Virchow-Robin Spaces: A Case Report.

ABSTRACT:

SUBMITTER: Shoeibi A

PROVIDER: S-EPMC6353514 | biostudies-literature | 2017 Jul-Aug

REPOSITORIES: biostudies-literature

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Levodopa-Responsive Parkinsonism Associated with Giant Virchow-Robin Spaces: A Case Report.

Shoeibi Ali A Litvan Irene I

Movement disorders clinical practice 20170327 4

PMID: 30713969

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Project description:BackgroundIn typical patients with multiple system atrophy with predominant parkinsonism (MSA-P) levodopa is ineffective. However, there are some of these patients who respond well to levodopa treatment. Levodopa efficacy in MSA-P patients is thought to be related to the degree of putaminal damage, but the pathological causation between the putaminal involvement and levodopa efficacy has not been established in detail.ObjectiveThis study aimed to evaluate the neuropathological features of the nigrostriatal dopaminergic system in a "levodopa-responsive" MSA-P patient in comparison with "levodopa-unresponsive" conventional MSA-P patients.Materials and methodsClinicopathological findings were assessed in a 53-year-old Japanese man with MSA who presented with asymmetric parkinsonism, levodopa response, and later wearing-off phenomenon. During autopsy, the nigrostriatal pathology of presynaptic and postsynaptic dopaminergic receptor density and α-synuclein status were investigated. The other two patients with MSA-P were examined using the same pathological protocol.ResultsFour years after the onset, the patient died of sudden cardiopulmonary arrest. On autopsy, numerous α-synuclein-positive glial cytoplasmic inclusions in the basal ganglia, pons, and cerebellum were identified. The number of neurons in the putamen and immunoreactivity for dopamine receptors were well-preserved. In contrast, significant neuronal loss and decreased dopamine receptor immunoreactivity in the putamen were observed in the "levodopa-unresponsive" MSA-P control patients. These putaminal pathology results were consistent with the findings of premortem magnetic resonance imaging (MRI). All three patients similarly exhibited severe neuronal loss in the substantia nigra and decreased immunoreactivity for dopamine transporter.ConclusionLevodopa responsiveness in patients with MSA-P may be corroborated by the normal putamen on MRI and the preserved postsynaptic nigrostriatal dopaminergic system on pathological examination. The results presented in this study may provide a rationale for continuation of levodopa treatment in patients diagnosed with MSA-P.

Dataset Information

Levodopa-Responsive Parkinsonism Associated with Giant Virchow-Robin Spaces: A Case Report.

Publications

Levodopa-Responsive Parkinsonism Associated with Giant Virchow-Robin Spaces: A Case Report.

Similar Datasets

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