Low- q Bicelles Are Mixed Micelles.
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ABSTRACT:
SUBMITTER: Caldwell TA
PROVIDER: S-EPMC6353637 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Low- q Bicelles Are Mixed Micelles.
Caldwell Tracy A TA Baoukina Svetlana S Brock Ashton T AT Oliver Ryan C RC Root Kyle T KT Krueger Joanna K JK Glover Kerney Jebrell KJ Tieleman D Peter DP Columbus Linda L
The journal of physical chemistry letters 20180725 15
Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of "isotropic" bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the classic bicelle that contains lipids in the core and detergent in the rim. Thus not all isotropic bicelles are bilayer-like. ...[more]
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