Ontology highlight
ABSTRACT:
SUBMITTER: Shamri R
PROVIDER: S-EPMC6353669 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Shamri Revital R Young Kristen M KM Weller Peter F PF
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20181119 2
<h4>Background</h4>Eosinophil-associated RNases (EARs) are stored preformed in eosinophil cytoplasmic secretory granules and have a key role in eosinophil effector functions in host defence and inflammatory disorders. However, the secretion mechanisms of EARs are poorly understood.<h4>Objective</h4>Our study aimed to understand the involvement of cytoskeleton machinery in EAR secretion.<h4>Methods</h4>Fresh human and mouse eosinophils were stimulated with CCL11, and the secretion of enzymaticall ...[more]