The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain.
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ABSTRACT:
SUBMITTER: Robinson RR
PROVIDER: S-EPMC6354220 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
The role of glial-neuronal metabolic cooperation in modulating progression of multiple sclerosis and neuropathic pain.
Robinson Rachel R RR Dietz Alina K AK Maroof Asif M AM Asmis Reto R Forsthuber Thomas G TG
Immunotherapy 20190201 2
While the etiology of multiple sclerosis (MS) remains unclear, research from the clinic and preclinical models identified the essential role of inflammation and demyelination in the pathogenesis of MS. Current treatments focused on anti-inflammatory processes are effective against acute episodes and relapsing-remitting MS, but patients still move on to develop secondary progressive MS. MS progression is associated with activation of microglia and astrocytes, and importantly, metabolic dysfunctio ...[more]
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