Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC6354242 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Yang Shicheng S Ji Yun Y Gattinoni Luca L Zhang Ling L Yu Zhiya Z Restifo Nicholas P NP Rosenberg Steven A SA Morgan Richard A RA
Cancer immunology, immunotherapy : CII 20121204 4
The genetic modification of CD8+ T cells using anti-tumor T-cell receptors (TCR) or chimeric antigen receptors is a promising approach for the adoptive cell therapy of patients with cancer. We previously developed a simplified method for the clinical-scale generation of central memory-like (Tcm) CD8+ T cells following transduction with lentivirus encoding anti-tumor TCR and culture in the presence of IL-2. In this study, we compared different cytokines or combinations of IL-2, IL-7, IL-12, IL-15 ...[more]