Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
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ABSTRACT:
SUBMITTER: Ziegler PK
PROVIDER: S-EPMC6354256 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler Paul K PK Bollrath Julia J Pallangyo Charles K CK Matsutani Takaji T Canli Özge Ö De Oliveira Tiago T Diamanti Michaela A MA Müller Nina N Gamrekelashvili Jaba J Putoczki Tracy T Horst David D Mankan Arun K AK Öner Meryem G MG Müller Susanna S Müller-Höcker Josef J Kirchner Thomas T Slotta-Huspenina Julia J Taketo M Mark MM Reinheckel Thomas T Dröse Stefan S Larner Andrew C AC Wels Winfried S WS Ernst Matthias M Greten Tim F TF Arkan Melek C MC Korn Thomas T Wirth Dagmar D Greten Florian R FR
Cell 20180614 1
In colorectal cancer patients, a high density of cytotoxic CD8<sup>+</sup> T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/β-catenin-dependent autochthonous models of sporadic intestinal tumorigenesis, we unravel a complex intracellular process in intestinal epithelial cells (IECs) that controls the induction of a CD8<sup>+</sup> T cell based adaptive immune response. Elevated mitophagy in IECs causes iron(II)-accumulation in epithelial l ...[more]
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