Ontology highlight
ABSTRACT:
SUBMITTER: Ziegler PK
PROVIDER: S-EPMC6354256 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell 20180614 1
In colorectal cancer patients, a high density of cytotoxic CD8<sup>+</sup> T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/β-catenin-dependent autochthonous models of sporadic intestinal tumorigenesis, we unravel a complex intracellular process in intestinal epithelial cells (IECs) that controls the induction of a CD8<sup>+</sup> T cell based adaptive immune response. Elevated mitophagy in IECs causes iron(II)-accumulation in epithelial l ...[more]