Ontology highlight
ABSTRACT:
SUBMITTER: Armitage J
PROVIDER: S-EPMC6354546 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Armitage Jane J Holmes Michael V MV Preiss David D
Journal of the American College of Cardiology 20190201 4
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl ester between high-density lipoprotein (HDL) and apolipoprotein B100-containing lipoproteins. Evidence from genetic studies that variants in the CETP gene were associated with higher blood HDL cholesterol, lower low-density lipoprotein cholesterol, and lower risk of coronary heart disease suggested that pharmacological inhibition of CETP may be beneficial. To date, 4 CETP inhibitors have entered phase ...[more]