Ontology highlight
ABSTRACT:
SUBMITTER: Hayes MN
PROVIDER: S-EPMC6354590 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hayes Madeline N MN McCarthy Karin K Jin Alexander A Oliveira Mariana L ML Iyer Sowmya S Garcia Sara P SP Sindiri Sivasish S Gryder Berkley B Motala Zainab Z Nielsen G Petur GP Borg Jean-Paul JP van de Rijn Matt M Malkin David D Khan Javed J Ignatius Myron S MS Langenau David M DM
Cell stem cell 20180301 3
Tumor growth and relapse are driven by tumor propagating cells (TPCs). However, mechanisms regulating TPC fate choices, maintenance, and self-renewal are not fully understood. Here, we show that Van Gogh-like 2 (Vangl2), a core regulator of the non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway, affects TPC self-renewal in rhabdomyosarcoma (RMS)-a pediatric cancer of muscle. VANGL2 is expressed in a majority of human RMS and within early mononuclear progenitor cells. VANGL2 depletion inhib ...[more]