Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunction.
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ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC6354623 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
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Mineralocorticoid receptor: A hidden culprit for hemodialysis vascular access dysfunction.
Chen Bohan B Wang Pei P Brem Andrew A Dworkin Lance L Liu Zhangsuo Z Gong Rujun R
EBioMedicine 20181205
Hemodialysis vascular access dysfunction is a common and intractable problem in clinical practice with no definitive therapy yet available. As a key mediator of vascular and cardiac maladaptive remodeling, mineralocorticoid receptor (MR) plays a pivotal role in vascular fibrosis and intimal hyperplasia (IH) and is potentiated locally in hemodialysis vascular access following diverse injuries, like barotrauma, cannulation and shear stress. MR-related genomic and non-genomic pathways are responsib ...[more]
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