Ontology highlight
ABSTRACT:
SUBMITTER: Le Roux AL
PROVIDER: S-EPMC6354742 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Le Roux Anabel-Lise AL Mohammad Irrem-Laareb IL Mateos Borja B Arbesú Miguel M Gairí Margarida M Khan Farman Ali FA Teixeira João M C JMC Pons Miquel M
iScience 20190114
The c-Src oncogene is anchored to the cytoplasmic membrane through its N-terminal myristoylated SH4 domain. This domain is part of an intramolecular fuzzy complex with the SH3 and Unique domains. Here we show that the N-terminal myristoyl group binds to the SH3 domain in the proximity of the RT loop, when Src is not anchored to a lipid membrane. Residues in the so-called Unique Lipid Binding Region modulate this interaction. In the presence of lipids, the myristoyl group is released from the SH3 ...[more]