Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells.
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ABSTRACT:
SUBMITTER: Anderson MW
PROVIDER: S-EPMC6354781 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells.
Anderson Matthew W MW Moss Joanna J JJ Szalai Robert R Lane Jon D JD
iScience 20190114
Protein kinase B/AKT is a highly connected protein involved in a range of signaling pathways. Although it is known to regulate several proteins in the apoptotic pathway, its system-level effects remain poorly understood. We investigated the dynamic interactions between AKT and key apoptotic proteins and constructed a deterministic ordinary differential equation protein interaction model of extrinsic apoptosis. Incorporating AKT and its indirect inhibitor, phosphatase and tensin homolog (PTEN), t ...[more]
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