Ontology highlight
ABSTRACT:
SUBMITTER: Zhu L
PROVIDER: S-EPMC6355216 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhu Luchang L Olsen Randall J RJ Beres Stephen B SB Eraso Jesus M JM Saavedra Matthew Ojeda MO Kubiak Samantha L SL Cantu Concepcion C CC Jenkins Leslie L Charbonneau Amelia R L ARL Waller Andrew S AS Musser James M JM
The Journal of clinical investigation 20190122 2
Necrotizing fasciitis and myositis are devastating infections characterized by high mortality. Group A streptococcus (GAS) is a common cause of these infections, but the molecular pathogenesis is poorly understood. We report a genome-wide analysis using serotype M1 and M28 strains that identified GAS genes contributing to necrotizing myositis in nonhuman primates (NHP), a clinically relevant model. Using transposon-directed insertion-site sequencing (TraDIS), we identified 126 and 116 GAS genes ...[more]