Ontology highlight
ABSTRACT:
SUBMITTER: Lang L
PROVIDER: S-EPMC6356571 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Cells 20190109 1
Fibroblast growth factor receptor 4 (FGFR4), a tyrosine kinase receptor for FGFs, is involved in diverse cellular processes, including the regulation of cell proliferation, differentiation, migration, metabolism, and bile acid biosynthesis. High activation of FGFR4 is strongly associated with the amplification of its specific ligand FGF19 in many types of solid tumors and hematologic malignancies, where it acts as an oncogene driving the cancer development and progression. Currently, the develop ...[more]