Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus.
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ABSTRACT:
SUBMITTER: Batista MN
PROVIDER: S-EPMC6356660 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Natural Products Isolated from Oriental Medicinal Herbs Inactivate Zika Virus.
Batista Mariana N MN Braga Ana Cláudia S ACS Campos Guilherme Rodrigues Fernandes GRF Souza Marcos Michel MM Matos Renata Prandini Adum de RPA Lopes Tairine Zara TZ Candido Natalia Maria NM Lima Maria Leticia Duarte MLD Machado Francielly Cristina FC Andrade Stephane Tereza Queiroz de STQ Bittar Cíntia C Nogueira Maurício L ML Carneiro Bruno M BM Mariutti Ricardo B RB Arni Raghuvir Krishnaswamy RK Calmon Marilia Freitas MF Rahal Paula P
Viruses 20190111 1
Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was ...[more]
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