Treatment of Parkinson's Disease through Personalized Medicine and Induced Pluripotent Stem Cells.

ABSTRACT: Parkinson's Disease (PD) is an intractable disease resulting in localized neurodegeneration of dopaminergic neurons of the substantia nigra pars compacta. Many current therapies of PD can only address the symptoms and not the underlying neurodegeneration of PD. To better understand the pathophysiological condition, researchers continue to seek models that mirror PD's phenotypic manifestations as closely as possible. Recent advances in the field of cellular reprogramming and personalized medicine now allow for previously unattainable cell therapies and patient-specific modeling of PD using induced pluripotent stem cells (iPSCs). iPSCs can be selectively differentiated into a dopaminergic neuron fate naturally susceptible to neurodegeneration. In iPSC models, unlike other artificially-induce

SUBMITTER: Stoddard-Bennett T 

PROVIDER: S-EPMC6357081 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature