Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC6357304 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Liu Guoyan G Yin Shulei S Li Ping P Han Yanmei Y Zheng Yuejuan Y Zhang Yi Y Liu Shuxun S Li Jiangyan J Guo Ziyi Z Tao Yijie Y An Huazhang H Xu Sheng S Yu Yizhi Y
American journal of translational research 20190115 1
KLRL1 is a member of C-type lectin-like receptors (CLEC) and preferentially expressed on the surface of immune cells. We have previously illustrated its inhibitory role in Natural killer (NK) cells. Though cloned from dendritic cells (DCs), its role in DCs has not been fully identified. Here, we found that mKLRL1 markedly decreased during DC maturation; mKLRL1-modifed DCs showed enhanced phagocytic capability and reduced ability to induce T cell proliferation, which mimics immature DCs. Further ...[more]