Network-based identification of critical regulators as putative drivers of human cleft lip.

ABSTRACT:

Background

Cleft lip (CL) is one of the most common congenital birth defects with complex etiology. While genome-wide association studies (GWAS) have made significant advances in our understanding of mutations and their related genes with potential involvement in the etiology of CL, it remains unknown how these genes are functionally regulated and interact with each other in lip development. Currently, identifying the disease-causing genes in human CL is urgently needed. So far, the causative CL genes have been largely undiscovered, making it challenging to design experiments to validate the functional influence of the mutations identified from large genomic studies such as CL GWAS.

Results

Transcription factors (TFs) and microRNAs (miRNAs) are two important regulators in ce

SUBMITTER: Li A 

PROVIDER: S-EPMC6357351 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature