Ontology highlight
ABSTRACT:
SUBMITTER: Al-Soudi A
PROVIDER: S-EPMC6357433 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Al-Soudi A A Doorenspleet M E ME Esveldt R E RE Burgemeister L T LT Hak A E AE van den Born B J H BJH Tas S W SW van Vollenhoven R F RF Klarenbeek P L PL de Vries N N
Arthritis research & therapy 20190131 1
<h4>Objectives</h4>An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4<sup>+</sup>) B cells and plasma cells are implicated in the pathogenesis of GPA. We hypothesized that the presence of these cells in peripheral blood could serve as disease activity parameter in GPA.<h4>Methods</h4>We included 35 proteinase 3-antineutrophil cytoplasmic antibodies-positive patients with GPA in a cross-sectional study. Activ ...[more]