A cellulose-based photoacoustic sensor to measure heparin concentration and activity in human blood samples.
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ABSTRACT:
SUBMITTER: Jeevarathinam AS
PROVIDER: S-EPMC6357780 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
A cellulose-based photoacoustic sensor to measure heparin concentration and activity in human blood samples.
Jeevarathinam Ananthakrishnan Soundaram AS Pai Navin N Huang Kevin K Hariri Ali A Wang Junxin J Bai Yuting Y Wang Lu L Hancock Tiffany T Keys Stanley S Penny William W Jokerst Jesse V JV
Biosensors & bioelectronics 20181208
Heparin is an indispensable drug in anticoagulation therapy but with a narrow therapeutic window, which dictates regular testing and dose adjustment. However, current monitoring tools have a long turnaround time or are operator intensive. In this work, we describe a cellulose-based photoacoustic sensor for heparin. The sensors have a turnaround time of 6 min for whole blood samples and 3 min for plasma samples regardless of heparin concentration. These sensors have a limit of detection of 0.28 U ...[more]
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