Ontology highlight
ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC6358635 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nature medicine 20180604 6
A central goal of HIV-1 vaccine research is the elicitation of antibodies capable of neutralizing diverse primary isolates of HIV-1. Here we show that focusing the immune response to exposed N-terminal residues of the fusion peptide, a critical component of the viral entry machinery and the epitope of antibodies elicited by HIV-1 infection, through immunization with fusion peptide-coupled carriers and prefusion stabilized envelope trimers, induces cross-clade neutralizing responses. In mice, the ...[more]