Ontology highlight
ABSTRACT:
SUBMITTER: Sevy AM
PROVIDER: S-EPMC6358683 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sevy Alexander M AM Wu Nicholas C NC Gilchuk Iuliia M IM Parrish Erica H EH Burger Sebastian S Yousif Dina D Nagel Marcus B M MBM Schey Kevin L KL Wilson Ian A IA Crowe James E JE Meiler Jens J
Proceedings of the National Academy of Sciences of the United States of America 20190114 5
Influenza is a yearly threat to global public health. Rapid changes in influenza surface proteins resulting from antigenic drift and shift events make it difficult to readily identify antibodies with broadly neutralizing activity against different influenza subtypes with high frequency, specifically antibodies targeting the receptor binding domain (RBD) on influenza HA protein. We developed an optimized computational design method that is able to optimize an antibody for recognition of large pan ...[more]