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Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach.

ABSTRACT: Inhibitors of chymase have good potential to provide a novel therapeutic approach for the treatment of cardiovascular diseases. We used a computational approach based on pharmacophore modeling, docking, and molecular dynamics simulations to evaluate the potential ability of 13 natural compounds from chamomile extracts to bind chymase enzyme. The results indicated that some chamomile compounds can bind to the active site of human chymase. In particular, chlorogenic acid had a predicted binding energy comparable or even better than that of some known chymase inhibitors, interacted stably with key amino acids in the chymase active site, and appeared to be more selective for chymase than other serine proteases. Therefore, chlorogenic acid is a promising starting point for developing new chymase inhibitors.

SUBMITTER: Dubey A

PROVIDER: S-EPMC6358779 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach.

Dubey Amit A Dotolo Serena S Ramteke Pramod W PW Facchiano Angelo A Marabotti Anna A

Biomolecules 20181221 1

Inhibitors of chymase have good potential to provide a novel therapeutic approach for the treatment of cardiovascular diseases. We used a computational approach based on pharmacophore modeling, docking, and molecular dynamics simulations to evaluate the potential ability of 13 natural compounds from chamomile extracts to bind chymase enzyme. The results indicated that some chamomile compounds can bind to the active site of human chymase. In particular, chlorogenic acid had a predicted binding en ...[more]

PMID: 30583487

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Dataset Information

Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach.

Publications

Searching for Chymase Inhibitors among Chamomile Compounds Using a Computational-Based Approach.

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