Network-Based Assessment of Adverse Drug Reaction Risk in Polypharmacy Using High-Throughput Screening Data.
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ABSTRACT:
SUBMITTER: de Anda-Jauregui G
PROVIDER: S-EPMC6358820 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Network-Based Assessment of Adverse Drug Reaction Risk in Polypharmacy Using High-Throughput Screening Data.
de Anda-Jáuregui Guillermo G Guo Kai K Hur Junguk J
International journal of molecular sciences 20190117 2
The risk of adverse drug reactions increases in a polypharmacology setting. High-throughput drug screening with transcriptomics applied to human cells has shown that drugs have effects on several molecular pathways, and these affected pathways may be predictive proxy for adverse drug reactions. Depending on the way that different drugs may contribute to adverse drug reactions, different options may exist in the clinical setting. Here, we formulate a network framework to integrate the relationshi ...[more]
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