Ontology highlight
ABSTRACT:
SUBMITTER: Liu C
PROVIDER: S-EPMC6358911 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Liu Chen C Wu Pengxiang P Zhu He H Grieco Paolo P Yu Ruihe R Gao Xinmei X Wu Guiyue G Wang Dong D Xu Hanmei H Qi Weiyan W
Molecules (Basel, Switzerland) 20190118 2
A lack of specificity is restricting the further application of conotoxin from <i>Conus bullatus</i> (<i>BuIA</i>). In this study, an analogue library of <i>BuIA</i> was established and virtual screening was used, which identified high α7 nicotinic acetylcholine receptor (nAChR)-selectivity analogues. The analogues were synthesized and tested for their affinity to functional human α7 nAChR and for the regulation of intracellular calcium ion capacity in neurons. Immunofluorescence, flow cytometry ...[more]