Dataset Information

Functionalized ?-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier.

ABSTRACT: Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with ?-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized ?-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO?@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-?-CD and ethylenediamine-?-CD (EDA-?-CD) were immobilized on the surface of SiO?@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the ?-CD on the SiO?@Ag NPs and then successfully released. Neither cysteinyl-?-CD and EDA-?-CD showed cytotoxicity, while DOX-loaded cysteinyl-?-CD and EDA-?-CD showed a significant decrease in cell viability in cancer cells. The SiO?@Ag NPs with ?-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.

SUBMITTER: Kang EJ

PROVIDER: S-EPMC6359520 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier.

Kang Eun Ji EJ Baek Yu Mi YM Hahm Eunil E Lee Sang Hun SH Pham Xuan-Hung XH Noh Mi Suk MS Kim Dong-Eun DE Kim Dong-Eun DE Jun Bong-Hyun BH

International journal of molecular sciences 20190114 2

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO₂@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO₂ ...[more]

PMID: 30646562

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Project description:BACKGROUND:In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, and still often fail. Drug-loaded magnetic nanoparticles are very promising for local selective therapy, enabling lower systemic antibiotic doses and reducing adverse side effects. The idea of the following study was the local accumulation of such nanoparticles by an externally applied magnetic field combined with a magnetizable implant. The examination of the biodistribution of the nanoparticles, their effective accumulation at the implant and possible adverse side effects were the focus. In a BALB/c mouse model (n?=?50) ferritic steel 1.4521 and Ti90Al6V4 (control) implants were inserted subcutaneously at the hindlimbs. Afterwards, magnetic nanoporous silica nanoparticles (MNPSNPs), modified with rhodamine B isothiocyanate and polyethylene glycol-silane (PEG), were administered intravenously. Directly/1/7/21/42 day(s) after subsequent application of a magnetic field gradient produced by an electromagnet, the nanoparticle biodistribution was evaluated by smear samples, histology and multiphoton microscopy of organs. Additionally, a pathohistological examination was performed. Accumulation on and around implants was evaluated by droplet samples and histology. RESULTS:Clinical and histological examinations showed no MNPSNP-associated changes in mice at all investigated time points. Although PEGylated, MNPSNPs were mainly trapped in lung, liver, and spleen. Over time, they showed two distributional patterns: early significant drops in blood, lung, and kidney and slow decreases in liver and spleen. The accumulation of MNPSNPs on the magnetizable implant and in its area was very low with no significant differences towards the control. CONCLUSION:Despite massive nanoparticle capture by the mononuclear phagocyte system, no significant pathomorphological alterations were found in affected organs. This shows good biocompatibility of MNPSNPs after intravenous administration. The organ uptake led to insufficient availability of MNPSNPs in the implant region. For that reason, among others, the nanoparticles did not achieve targeted accumulation in the desired way, manifesting future research need. However, with different conditions and dimensions in humans and further modifications of the nanoparticles, this principle should enable reaching magnetizable implant surfaces at any time in any body region for a therapeutic reason.

Dataset Information

Functionalized ?-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier.

Publications

Functionalized <i>β</i>-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier.

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