Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC).

ABSTRACT: BACKGROUND/OBJECTIVES:This study examined the long-term relation of lipid-soluble micronutrients with diet quality as assessed by four a priori-defined dietary patterns. SUBJECTS/METHODS:In a prospective design, nutritional biomarkers (carotenoids, tocopherols, retinol, and coenzyme Q10) were measured using a validated HPLC-based assay. General linear models were applied to obtain covariate-adjusted means of biomarkers for tertiles of four a priori diet quality indices: Healthy Eating Index (HEI) 2010, Alternative HEI (AHEI) 2010, Alternate Mediterranean Diet Score (aMED), and Dietary Approaches to Stop Hypertension (DASH). For a subcohort of 8367 participants within the Multiethnic Cohort (MEC), diet was assessed by a validated quantitative food frequency questionnaire in 1993-96 and serum was collected in 2001-06. RESULTS:Participants with the highest diet-quality scores had significantly higher serum concentrations of all carotenoids, total tocopherols, and ?-tocopherol, whereas ?-tocopherol was inversely associated with diet quality. Adjusted means for the lowest vs. highest tertile of HEI 2010 were 1.2 vs. 1.5?mg/L for total carotenoids, 11.4 vs. 12.3?mg/L for total tocopherols, and 1.9 vs. 1.6?mg/L for ?-tocopherol (ptrend?

SUBMITTER: Aumueller N 

PROVIDER: S-EPMC6359995 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature